• It is increasingly argued that the immunosuppressive effects

  2021-12-09

  

  It is increasingly argued that the immunosuppressive effects of GCs are conferred indirectly by GR through the activation of genes encoding proteins that inhibit oleanolic acid of proinflammatory genes 86, 87, 88. Genomic studies offer another mechanism compatible with the idea that GC-mediated rep

• Polymerisation of HbS initiates the clinical complications o

  2021-12-09

  

  Polymerisation of HbS initiates the clinical complications of SCD (Bunn and Forget, 1986). The resulting sequelae are multiple and diverse, and their individual impact on pathogenesis is difficult to elucidate. Early changes include altered red cell membrane permeability (Gibson and Ellory, 2002, Le

• br Some general considerations on anterior pituitary cell ty

  2021-12-09

  

  Some general considerations on anterior pituitary cell type, models, sex and drugs Historically, real-time analysis of native endocrine anterior pituitary cell excitability has been somewhat limited and thus much of the pioneering work on anterior pituitary cell excitability and stimulus-secretio

• human leukocyte elastase br Concluding remarks br Introducti

  2021-12-09

  

  Concluding remarks Introduction The hair human leukocyte elastase of vestibular organs detect linear and rotational head movements, providing sensory information that is essential for normal postural and visual reflexes. Most vestibular hair cells are produced during embryonic development, bu

• In conclusion starting from the weakly potent

  2021-12-09

  

  In conclusion, starting from the weakly potent GSM , exploration of various spacer groups between the triazole ring and the aromatic Hydroxyfasudil mg led to the discovery of a new series of potent gamma secretase modulators, with an improved drug-like profile—compared with the originally reported

• In this work we constructed a versatile

  2021-12-09

  

  In this work, we constructed a versatile platform based on MoS2-loaded molecular beacon(MB) and HCR for miRNA detection with high sensitivity and low-background. In this method, the G-quadruplex/Thioflavin T (THT) as fluorescent signal output, which possesses a variety of advantages, such as label-f

• br Materials and methods br

  2021-12-09

  

  Materials and methods Results Discussion The distribution of FFA1 and FFA4 expressed in normal tissues is distinguishable. FFA1 is expressed in the restricted organ, such as pancreatic beta glycogen synthase kinase [18]. In contrast, FFA4 is highly expressed in the lung, gastrointestinal t

• br Experimental procedures br Conflicts of interests

  2021-12-09

  

  Experimental procedures Conflicts of interests Introduction Here we investigate differences in growth properties and short-term morphological changes in response to ET-1 in Chinese hamster ovary (CHO) cells stably and separately expressing ETA or ETB receptors. A stably transfected CHO syst

• br Introduction Glycolysis plays a key role in brain

  2021-12-08

  

  Introduction Glycolysis plays a key role in 20187 energy metabolism [[1], [2], [3]]. It is initiated mainly by hexokinase I (HKI), the major hexokinase isoform of the brain ([3,4] and references therein). Up to 90% of brain HKI is bound to the mitochondrial outer membrane (MOM) through the voltag

• Treatment with probiotics can also be

  2021-12-08

  

  Treatment with probiotics can also be used to alter the microbiota profile of CF patients. One study reports that administration of the probiotic Lactobacillus Reuteri improved digestive health and inflammation [112]. The fecal microbial profile changed, showing a decrease in Proteobacteria and an i

• br Materials and methods br Acknowledgements The

  2021-12-08

  

  Materials and methods Acknowledgements The following reagents were obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: SIVagm155-4 from Dr. Vanessa Hirsch and Dr. Philip Johnson; Anti-SIVmac251 Polyclonal; SIVagm tan-1 infectious molecular UNC2025 from Drs. Marcelo So

• CARIPORIDE br Materials and methods br Results br

  2021-12-08

  

  Materials and methods Results Discussion Although large-scale purification of homogeneous and functional membrane proteins is challenging, it is essential for biochemical, biophysical and structural characterization. This is particularly true for human P-gp, as its atomic structure has only

• Natural products are a diverse and interesting source

  2021-12-08

  

  Natural products are a diverse and interesting source for the discovery of new lead structures (Newman and Cragg, 2016). After a successful era of natural product research, many pharmaceutical companies stopped their investment in natural product-driven drug discovery in the 1990s. The reason behind

• We next investigated whether pharmaceutical inhibition of th

  2021-12-08

  

  We next investigated whether pharmaceutical inhibition of the PI3K pathway was synergistic with FGFR inhibition using BKM120, a pan-PI3K inhibitor with modest antitumor activity in cancer patients, as a single agent. We found that RT112 (- translocation) and JMSU1 ( amplification) were not signifi

• br Acknowledgements This work was in

  2021-12-08

  

  Acknowledgements This work was in part supported by the FöFoLe program by Ludwig-Maximilians-Universität München (to T.S.), the Deutsche Forschungsgemeinschaft (DFG) CO 291/5-2, the Human Frontier Science Program (HFSP) RGP0013, the Helmholtz Validation Funds (Helmholtz Association of German Rese

14292 records 518/953 page Previous Next First page 上5页 516517518519520 下5页 Last page